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Can I run Gemma 4 12B on AMD Radeon RX 7900 XTX (24GB)?

Compatibility verdict VRAM threshold engine
Yes, it runs GPU accelerated ~88 tok/s est.

Yes. Gemma 4 12B runs on AMD Radeon RX 7900 XTX (24GB) at Q4_K_M (~8.7 GB of ~23 GB usable).

Needs ~8.7 GB Device usable ~23 GB

Runs at Q4_K_M using ~8.7 GB of ~23 GB usable. You have room for Q8_0 for higher quality.

That figure is at a 4k context and moves about ±15% as context length changes. AMD Radeon RX 7900 XTX (24GB) leaves ~14.3 GB of headroom, room to step up to Q8_0 for higher quality.

Q4_K_M needed
~8.7 GB
Usable on device
~23 GB
Device memory
24 GB
Best quant
Q4_K_M
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Which quant fits

Quant ladder vs ~23 GB usable
Q2_K
~6.6 GB
Q3_K_M
~7.5 GB
Q4_K_M
~8.7 GB
Q5_K_M
~10.2 GB
Q6_K
~11.4 GB
Q8_0
~14.3 GB
FP16
~25.4 GB
The line marks AMD Radeon RX 7900 XTX (24GB)'s ~23 GB budget; rungs past it are too large.

Running cost · estimate

Power & economics est.
Power draw
~355 W
Electricity / 1M tokens
~$0.17
Pays for itself after
~3,027M tok

At ~$0.15/kWh and the estimated ~88 tok/s, a million generated tokens costs about $0.17 in electricity. Versus a hosted API at ~$0.5 per million tokens, the ~$999 AMD Radeon RX 7900 XTX (24GB) pays for itself after roughly 3,027 million tokens, so local hardware is mostly a fixed cost, not a per-token one. TDP is the peak draw, so this is an upper bound. Assumptions.

Run it

Install commands Windows

Pick your tool. All 3 load the same Q4_K_M weights.

Ollama
$ ollama run gemma4:12b
llama.cpp
$ llama-cli -hf unsloth/gemma-4-12B-it-GGUF:Q4_K_M
LM Studio
$ lms get unsloth/gemma-4-12B-it-GGUF
Model Gemma
Parameters
12B
Q4_K_M size
7.12 GB
Q8_0 size
12.67 GB
Context
256k
Ollama tag
gemma4:12b
Full Gemma 4 12B requirements →
Device Windows
Memory
24 GB vram
Usable for weights
~23 GB
Power draw
~355 W
Best runtime
Ollama (ROCm) / llama.cpp ROCm (Linux)
Best models for AMD Radeon RX 7900 XTX (24GB) →

You could also run

Run Gemma 4 12B on other hardware

FAQ

Can AMD Radeon RX 7900 XTX (24GB) run Gemma 4 12B?

Yes. Gemma 4 12B runs on AMD Radeon RX 7900 XTX (24GB) at Q4_K_M (~8.7 GB of ~23 GB usable).

How much memory does Gemma 4 12B need?

AMD Radeon RX 7900 XTX (24GB) has room to spare. At Q4_K_M the weights are ~7.12 GB; with KV cache and runtime overhead, budget ~8.7 GB at a 4k context.

What is the best tool to run Gemma 4 12B on Windows?

LM Studio for a simple setup; Ollama (CUDA) for the most speed. AMD GPUs run via Vulkan/ROCm at roughly half CUDA throughput. NVIDIA is the smooth path on Windows.

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Sources

Weights are measured from GGUF files; KV cache and overhead are computed, so totals can vary ~15% with context and runtime. Any tok/s is a bandwidth estimate. See methodology.